Yoshihiro Fukumoto Selected Research

fasudil (AT 877)

1/2014	Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice.
1/2014	Combination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension and survival in rats.
8/2011	Rho-kinase: important new therapeutic target in cardiovascular diseases.
3/2010	Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension.
2/2009	Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.
3/2007	Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina.
2/2007	Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.
12/2006	Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.
10/2004	[Inhibition of Rho-kinase by fasudil preventing anginal attacks associated with spastic angina: a case report].
9/2004	Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Yoshihiro Fukumoto Research Topics

Disease

20	Pulmonary Hypertension 11/2017 - 12/2006
18	Heart Failure 03/2022 - 02/2006
15	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 08/2011
13	Coronary Artery Disease (Coronary Atherosclerosis) 10/2022 - 02/2006
13	Inflammation (Inflammations) 03/2022 - 09/2002
13	Hypertension (High Blood Pressure) 12/2021 - 07/2003
13	Myocardial Ischemia (Ischemic Heart Diseases) 01/2020 - 09/2004
13	Myocardial Infarction 01/2020 - 05/2003
12	Ischemia 08/2020 - 03/2006
11	Atherosclerosis 04/2022 - 03/2008
11	Pulmonary Arterial Hypertension 01/2018 - 02/2007
9	Hypoxia (Hypoxemia) 01/2015 - 12/2006
8	Insulin Resistance 04/2021 - 10/2014
6	Stroke (Strokes) 01/2021 - 09/2010
5	Glucose Intolerance 01/2022 - 06/2012
5	Neoplasms (Cancer) 10/2021 - 01/2014
5	Reperfusion Injury 01/2020 - 03/2006
5	Atherosclerotic Plaque (Atheroma) 01/2015 - 09/2002
5	Fibrosis (Cirrhosis) 01/2014 - 03/2008
5	Arteriosclerosis 01/2013 - 01/2004
5	Infarction (Infarctions) 01/2012 - 03/2006
5	Shock 10/2011 - 02/2008
4	Chronic Limb-Threatening Ischemia 11/2022 - 01/2019
4	Chronic Renal Insufficiency 03/2022 - 01/2015
4	Pathologic Constriction (Stenosis) 07/2021 - 10/2004
4	Aortic Dissection 05/2020 - 10/2017
4	Type 2 Diabetes Mellitus (MODY) 01/2020 - 11/2013
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2019 - 01/2014
4	Hypertrophy 06/2014 - 03/2008
3	Ventricular Tachycardia 10/2022 - 02/2006
3	Hyperuricemia 04/2022 - 01/2021
3	Frailty 12/2021 - 02/2021
3	Cognitive Dysfunction 12/2021 - 01/2017
3	Thrombosis (Thrombus) 04/2020 - 02/2008
3	Angina Pectoris 01/2019 - 11/2005
3	Body Weight (Weight, Body) 01/2019 - 12/2007
3	Abdominal Aortic Aneurysm 03/2018 - 01/2017
3	Muscle Spasticity (Spastic) 12/2017 - 09/2004
3	Acute Coronary Syndrome 10/2017 - 10/2004
3	Hip Osteoarthritis (Coxarthrosis) 06/2017 - 01/2012
3	Hemorrhage 03/2016 - 02/2006
3	Vascular Remodeling 01/2015 - 04/2007
3	Right Ventricular Hypertrophy 06/2014 - 12/2006
3	Ventricular Remodeling 01/2014 - 08/2010
3	Chest Pain (Chest Pains) 03/2010 - 10/2004
2	Sarcoidosis (Schaumann Disease) 10/2022 - 10/2021
2	Carotid Artery Diseases 04/2022 - 01/2020
2	Hypotension (Low Blood Pressure) 03/2022 - 01/2019
2	Aortic Valve Stenosis (Aortic Stenosis) 03/2022 - 01/2020
2	Sarcopenia 01/2022 - 01/2020
2	Death (Near-Death Experience) 07/2021 - 09/2010

Drug/Important Bio-Agent (IBA)

22	rho-Associated KinasesIBA 06/2014 - 01/2004
11	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2022 - 06/2007
11	fasudil (AT 877)IBA 01/2014 - 01/2004
9	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2013
7	LipidsIBA 10/2022 - 09/2002
7	Vasodilator Agents (Vasodilators)IBA 01/2013 - 09/2004
6	MonocrotalineIBA 01/2014 - 12/2006
5	LDL CholesterolIBA 10/2022 - 12/2014
5	C-Reactive ProteinIBA 02/2021 - 07/2003
5	Angiotensin IIIBA 01/2020 - 02/2009
4	pitavastatin (itavastatin)FDA Link 10/2022 - 01/2018
4	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2014
4	CollagenIBA 01/2014 - 01/2004
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2011 - 03/2007
3	Febuxostat FDA Link 04/2022 - 01/2021
3	HDL CholesterolIBA 01/2022 - 05/2015
3	AlbuminsIBA 12/2021 - 01/2016
3	Prasugrel Hydrochloride FDA Link 06/2021 - 10/2017
3	Clopidogrel (Plavix)FDA Link 06/2021 - 10/2017
3	Triglycerides (Triacylglycerol)IBA 04/2021 - 05/2015
3	CalciumIBA 02/2021 - 10/2004
3	Insulin (Novolin)FDA Link 12/2020 - 01/2019
3	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2020 - 09/2010
3	CytokinesIBA 01/2020 - 01/2015
3	Advanced Glycation End ProductsIBA 01/2020 - 01/2019
3	Proteins (Proteins, Gene)FDA Link 10/2019 - 01/2014
3	oxidized low density lipoproteinIBA 01/2018 - 09/2002
3	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2016 - 06/2014
3	Indicators and Reagents (Reagents)IBA 01/2011 - 12/2007
3	Lactic Acid (Lactate)FDA LinkGeneric 01/2009 - 11/2005
3	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 03/2008 - 10/2004
3	Monomeric GTP-Binding ProteinsIBA 08/2007 - 01/2004
2	Adrenal Cortex Hormones (Corticosteroids)IBA 10/2022 - 10/2021
2	AntioxidantsIBA 01/2022 - 05/2007
2	EnzymesIBA 12/2021 - 11/2015
2	GlyceraldehydeIBA 12/2021 - 10/2019
2	SaltsIBA 10/2021 - 01/2020
2	Opioid Analgesics (Opioids)IBA 07/2021 - 01/2020
2	omega-Chloroacetophenone (Mace)IBA 07/2021 - 09/2010

Therapy/Procedure

31	Therapeutics 10/2022 - 09/2004
9	Percutaneous Coronary Intervention 01/2022 - 02/2006
7	Stents 03/2022 - 01/2004
5	Extracorporeal Shockwave Therapy 08/2010 - 02/2006
4	Palliative Care (Palliative Therapy) 01/2022 - 01/2020
4	Resistance Training 01/2022 - 01/2014
3	Surgical Amputation (Amputations) 11/2022 - 01/2019
3	Endarterectomy (Thromboendarterectomy) 11/2017 - 01/2014
3	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 10/2011 - 09/2004
2	Defibrillators (Defibrillator) 10/2022 - 03/2021